Research
The GUt-Brain Axis
Ayurveda x Technology and Beyond
HUMAN VALUE
Dr. Kuver studies the gut-brain axis and Nano-tech therapeutic options for ANXIETY-LINKED neurodegenerative disorders.
Her work focuses on translating research findings into developing apps and non-invasive wearables to prevent neurodegeneration.
Integrative medicine and science, including Ayurveda, are essential to her research.
Dr. Kuver is aN AAC&U 2022 CONVERGENCE FELLOW & NINDS BRAINS 2019 Fellow.
The DOSHA app was created to improve preventative measures in anxiety-related neurodegeneration. (Trademark and copyright Aarti Kuver, PhD and Joel Alexander).
The DOSHA app is designed to measure biomarkers via non-invasive methods and work with the Apple watch. (Trademark and copyright Aarti Kuver, PhD and Joel Alexander).
Publications (Selected titles)
Kuver, A. The effects of natural nootropics on early stage cognitive impairment and anxiety. (In preparation).
Wang S, Duan M, Guan K, Zhou X, Zheng M, Shi X, Ye M, Guan W, Kuver A, Huang M, Liu Y, Dai K, Li X. (2019) Developmental neurotoxicity of reserpine exposure in zebrafish larvae (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 223:115-123. (Collaboration)
Dai K, Wang Y, Tai S, Ni H, Lian H, Yu Y, Liao W, Zheng C, Chen Q, Kuver A, Li J. (2018) Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis. Cardiovasc Ther. 36:e12477. (Collaboration)
Kuver A and Smith SS. (2016) Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization. Brain Res.120: 131-43.
Kuver A, Shen H, Smith SS. (2012) Regulation of the surface expression of α4β2δ GABAA receptors by high efficacy states. Brain Res. 1463:1-20.
Shen H, Sabaliauskas N, Sherpa A, Fenton AA, Stelzer A, Aoki C, Smith SS. (2010) A critical role for α4βδ GABAA receptors in shaping learning deficits at puberty in mice. Science. 327:1515-8. Acknowledgements: Kuver, A., Supplemental Figure 3.
Presentations (selected titles)
Kuver, A. (June 2021) Bridging basic sciences and non-invasive neurotechnologies to investigate, diagnose, and treat anxiety-driven neurodegenerative disorders along the gut-brain axis. 7th Annual BRAIN Initiative Investigators Meeting, Virtual.
Kuver, A. (November 2019) Treating early symptoms of Alzheimer’s Disease and related dementias with a gut-brain axis-targeted therapeutic. Alzheimer’s Disease Therapeutics: Alternatives to Amyloids,New York Academy of Sciences Brain and Behavior Discussion Group Symposia, New York, NY.
Kuver, A. (June 2018) Treatment of early-onset neurodegeneration and identification of putative pathways in neuroprotection of memory and cognition. Managing Neuropsychiatric Symptoms in Neurodegenerative Disease,New York Academy of Sciences Brain and Behavior Discussion Group Symposia, New York, NY.
Smith SS, Mohammad A, and Kuver A. (October 2013) Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors via a BDNF-mediated pathway. Society for Neuroscience Annual Meeting, San Diego, CA.
